Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand
نویسندگان
چکیده
The dinuclear dichloro complexes [(g-arene)2Ru2(l-Cl)2Cl2] and [(g-C5Me5)2M2(l-Cl)2Cl2] react with 2-(pyridine-2-yl)thiazole (pyTz) to afford the cationic complexes [(g-arene)Ru(pyTz)Cl] (arene = C6H6 1, p-PrC6H4Me 2 or C6Me6 3) and [(g-C5Me5)M(pyTz)Cl] (M = Rh 4 or Ir 5), isolated as the chloride salts. The reaction of 2 and 3with SnCl2 leads to the dinuclear heterometallic trichlorostannyl derivatives [(gp-PrC6H4Me)Ru(pyTz)(SnCl3)] (6) and [(g-C6Me6)Ru(pyTz)(SnCl3)] (7), respectively, also isolated as the chloride salts. The molecular structures of 4, 5 and 7 have been established by single-crystal X-ray structure analyses of the corresponding hexafluorophosphate salts. The in vitro anticancer activities of the metal complexes on human ovarian cancer cell lines A2780 and A2780cisR (cisplatin-resistant), as well as their interactions with plasmid DNA and the model protein ubiquitin, have been investigated.
منابع مشابه
Synthesis and Characterization of New Mercury (II) Complexes with Bidentate Chelating Schiff Base Iminopyridine Ligand
First, Schiff base iminopyridine ligands has been prepared by the condensation between primaryamines, different substituted anilines and active carbonyl group of pyridine carboxaldehyde, thenthe complexes [diiodo (3-ethylphenyl) pyridine-2-yl methylene amine] mercury(II), complex a,[dibromo (2,5-dimethylphenyl) pyridine-2-yl methylene amine] mercury(II) complex b, and[dinitrato bis-(2,6-dimethy...
متن کاملPotent Half-Sandwich Iridium(III) Anticancer Complexes Containing C∧N-Chelated and Pyridine Ligands
We report the synthesis and characterization of eight half-sandwich cyclopentadienyl IrIII pyridine complexes of the type [(η5-Cpxph)Ir(phpy)Z]PF6, in which Cpxph = C5Me4C6H5 (tetramethyl(phenyl)cyclopentadienyl), phpy = 2-phenylpyridine as C∧N-chelating ligand, and Z = pyridine (py) or a pyridine derivative. Three X-ray crystal structures have been determined. The monodentate py ligands blocke...
متن کاملPentamethylcyclopentadienyl rhodium and iridium complexes containing oxinato ligands
The neutral chloro complexes [(g-C5Me5)M(g-NC9H6O)Cl] as well as the cationic aqua complexes [(g-C5Me5)M(g-NC9H6O)(H2O)] (M = Rh, Ir) have been synthesized from the reaction of the dinuclear precursors [(g-C5Me5)MCl2]2 and 8-hydroxyquinoline. The single crystal X-ray structure analysis of [(g-C5Me5)Ir(g-NC9H6O)Cl] reveals for these complexes a piano-stool arrangement with the aromatic ligand, t...
متن کاملMono and dinuclear iridium, rhodium and ruthenium complexes containing chelating carboxylato pyrazine ligands: Synthesis, molecular structure and electrochemistry
The mononuclear complexes [(g-C5Me5)IrCl(L )] (1), [(g-C5Me5)RhCl(L )] (2), [(g-p-PrC6H4Me)RuCl(L )] (3) and [(gC6Me6)RuCl(L )] (4) have been synthesised from pyrazine-2-carboxylic acid (HL) and the corresponding complexes [{(gC5Me5)IrCl2}2], [{(g -C5Me5)RhCl2}2], [{(g -p-PrC6H4Me)RuCl2}2], and [{(g -C6Me6)RuCl2}2], respectively. The related dinuclear complexes [{(g-C5Me5)IrCl}2(l-L )] (5), [{(...
متن کاملThe Kinetic and Thermal Degradation Studies of N-(4-Acetyl-phenyl)-acetimidic Acid Pyridine-3-yl ester Metal(II) Complexes
Schiff base complexes of transition metals are of particular interest to inorganic chemists because of their structural, spectral and chemical properties, which are often strongly dependant on the nature of the ligand structure. Large number of metal (II) complexes with Schiff-base ligands has been extensively studied for their interesting structural specialties, applications and properties. Th...
متن کامل